Ngalaba na-anata ihe nnabata Spike glycoprotein (RBD) nke SARS-CoV-2 na-emekọrịta njikọ nke nje virus na ihe nnabata angiotensin na-agbanwe enzyme 2 (ACE2) n'elu sel mmadụ.Ya mere, mmekọrịta Spike-ACE2 bụ ihe dị mkpa na-ekpebi ihe kpatara nje nje virus. Otu ọhụrụ phylogenetic nke SARS-CoV-2 (usoro ọmụmụ B.1.1.7), nke na-egosipụta nnọchi amino acid na Spike RBD (N501Y mutation).
Dabere na nyocha ọhụrụ sitere na Ngalaba Ahụike UK, dabere na data nke usoro genome nke usoro, ọrịa na-efe efe na ụdị, ọrịa nke ụdị dị iche iche nke SARS-CoV-2 fọrọ nke nta ka ọ bụrụ 40-70% dị elu karịa ndị ọkà mmụta sayensị mgbanwe mgbanwe ndị ọzọ ghọtara. .Nzaghachi na nchọpụta ngwa ngwa bụ otu n'ime ihe mgbochi na njikwa dị mkpa.
A na-eji ngwa ahụ maka nyocha qualitative in vitro ịchọpụta mkpụrụ ndụ ihe nketa ORF1ab/N/S nke novel coronavirus 2019-nCoV n'ụdị akụkụ iku ume, na ịme mmụgharị mkpụrụ akwụkwọ na N501Y n'otu oge.
Ngwa ahụ na-anabata usoro ARMS, were S gene of novel coronavirus (2019-nCoV) dị ka mpaghara ebumnuche maka mmụgharị mkpụrụ akwụkwọ, na-echepụta primers na nyocha maka N501Y.
Ngwaahịa | Nkọwapụta | Chekwa okpomọkụ | Nkọwa |
Ngwa PCR Real Time maka akwụkwọ akụkọCoronavirus 2019-nCoV naAkwụkwọ akụkọ Coronavirus 2019-nCoVMgbanwe mkpụrụ ndụ ihe nketa (N501Y) | 48T | -20 ℃ | Nyocha: Ụdị anụ ọhịa nke N501Y,Ụdị mgbanwe nke N501Y, ORF1ab,N gene na njikwa ime |
Ndakọrịta template
- Oropharyngeal swabs
- Nasopharyngeal swab
- Mmiri Lavage Bronchoalveolar
- Sputum
Ngwa ngwa
- Ihe nchekwa mmeghachi omume RT-PCR
- Ngwakọta enzyme RT-PCR
- Ụdị anụ ọhịa dị mma njikwa
- Mgbanwe nke ọma njikwa
- Njikwa adịghị mma